Abstract: Hereditary transthyretin amyloidosis(ATTRv) is a rare autosomal dominant multisystem disease caused by pathogenic variations in the TTR gene, mainly affecting peripheral nerves, heart, digestive tract, eyes, kidneys, and leptomeninges, among others. The isolated single-organ involvement is uncommon, and multidisciplinary collaboration is required for the disease management.The age of onset and clinical manifestations of ATTRv patients vary greatly, and individualized management of each patient's systemic symptoms is needed. To this end, we organized domestic experts in Neurology, Cardiology, Gastroenterology, and Medical Genetics to write the ATTRv multidisciplinary management consensus. This consensus aims to improve the multidisciplinary management of ATTRv patients among clinical physicians in China, while also providing a reference for the prevention, control, and healthcare policy formulation of this disease in China.